Director, Center for Assistive Technology University at Buffalo The State University of New York Joe explores the related processes of knowledge translation (KT), technology transfer (TT), and commercial transactions (CT) in the context of technology-based innovation. For the past 25 years he has led projects that applied supply push, demand pull and corporate collaboration strategies to broker the market launch of over fifty new commercial products. At the same time, he contributed to understanding the underlying mechanisms through many peer-reviewed publications and conference presentations. These published findings are integrated with the relevant global literature within the Need to Knowledge (NtK) Model, as an evidence-based and operational framework for linking the 3 methodologies of scientific research, engineering development and industrial production. His primary conclusion is that each methodology is purposely designed to generate a different state of knowledge: conceptual discovery, prototype invention, and commercial innovation, respectively. All of this work is grounded within a series of national centers, funded by the U.S. Department of Education and the U.S. Department of Health and Human Services, conducted through an organized research unit, the Center for Assistive Technology  within the School of Public Health & Health Professions, University at Buffalo, New York.